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Hyaluronic Acid-Coated Carbon Nonwoven Fabrics as Potential Material for Repair of Osteochondral Defects for medical applications

Research and development

Authors:

  • Rajzer Izabella
    Institute of Textile Engineering and Polymer Materials, Faculty of Materials and Environment Science, University of Bielsko-Biala, Bielsko-Biała, Poland
  • Menaszek Elżbieta
    Departament of Cytobiology, Collegium Medicum, UJ Jagiellonian University, Kraków, Poland
  • Menaszek Elżbieta
    Department of Biomaterials, Faculty of Materials Engineering and Ceramics, AGH – University of Science and Technology, Kraków, Poland
  • Bacakova Lucie
    Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
  • Orzelski Maciej
    Department and Clinic of Animal Surgery, Faculty of Veterinary Medicine, University of Life Sciences, Lublin, Poland
  • Błażewicz Marta
    Department of Biomaterials, Faculty of Materials Engineering and Ceramics, AGH – University of Science and Technology, Kraków, Poland

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Abstract:

Damaged articular cartilage is known to have poor capacity for regeneration. Carbon fibres (CFs) have been widely investigated as cellular growth supports in cartilage tissue engineering. However, the long duration of the process of cartilage restoration limits the applicability of CFs implants in the treatment of cartilage tissue defects. Hyaluronic acid (HA) plays a key role in cartilage tissue development, repair and function. In the present study we focused on the in vitro and in vivo evaluation of two types of carbon nonwoven fabrics: HA modified and non-modified carbon nonwovens. The results of in vitro studies showed that cells attached well and retained their good viability in the carbon nonwoven matrix. The incorporation of hyaluronic acid resulted in the enhancement of cell proliferation. The results of in vivo studies showed a faster process of tissue regeneration in the case of HA modified carbon nonwovens. The results presented indicated that HA-modified carbon materials seem to be a suitable material for the treatment of osteochondral defects.

Tags:

cartilage, carbon fibres, nonwoven scaffolds, hyaluronic acid, biomaterials.

Citation:

Rajzer I, Menaszek E, Bacakova L, Orzelski M, Błażewicz M. Hyaluronic Acid-Coated Carbon Nonwoven Fabrics as Potential Material for Repair of Osteochondral Defects. FIBRES & TEXTILES in Eastern Europe 2013; 21, 3(99): 102-107.

Published in issue no 3 (99) / 2013, pages 102–107.

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