The aim of the present work was to develop new composite materials based on two biocompatible  polymers (sodium alginate and polycaprolactone) intended for use in the treatment of bone tissue defects. Tests carried out to obtain polymer-fibre composites using two resorbable polymers demonstrated the possibility of attaining composites with mechanical properties that are suitable from the point of view of their applications. Young’s modulus values for the composite systems analysed (254-389 MPa) are higher than for an unmodified PCL sheet. Irrespective of the fibrous phase used, the PCL matrix demonstrates stability in in vitro conditions. The constant pH values and small changes in the ionic conductance of the water indicate that these materials undergo gradual but slow degradation.

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Composites Based on Poly-e-Caprolactone and Calcium Alginate Fibres Containing Ceramic Nanoadditives for Use in Regenerative Medicine

Research and development

Authors:

  • Boguń Maciej
    Department of Man-Made Fibres, Faculty of Material Technologies and Textile Design, Technical University of Łódź, Łódź, Poland
  • Stodolak Ewa
    Department of Biomaterials, Faculty of Materials Engineering and Ceramics, AGH – University of Science and Technology, Kraków, Poland
  • Menaszek Elżbieta (j/w)
  • Menaszek Elżbieta
    Department of Cytologyge, Faculty of Pharmacy, CMUJ - Jagiellonian University Medical Collage, Kraków, Poland
  • Ścisłowska-Czarnecka Anna
    Department of Physiotherapy, Faculty of Rehabilitation, University School of Physical Educationg, Kraków, Poland

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Abstract:

The aim of the present work was to develop new composite materials based on two biocompatible  polymers (sodium alginate and polycaprolactone) intended for use in the treatment of bone tissue defects. Tests carried out to obtain polymer-fibre composites using two resorbable polymers demonstrated the possibility of attaining composites with mechanical properties that are suitable from the point of view of their applications. Young’s modulus values for the composite systems analysed (254-389 MPa) are higher than for an unmodified PCL sheet. Irrespective of the fibrous phase used, the PCL matrix demonstrates stability in in vitro conditions. The constant pH values and small changes in the ionic conductance of the water indicate that these materials undergo gradual but slow degradation.

Tags: alginate fibres, polycaprolactone, nanoadditives, hydroxyapatite, bioglass.

Citation: Boguń M., Stodolak E., Menaszek E., Ścisłowska-Czarnecka A.; Composites Based on Poly-e-Caprolactone and Calcium Alginate Fibres Containing Ceramic Nanoadditives for Use in Regenerative Medicine. FIBRES & TEXTILES in Eastern Europe 2011, Vol. 19, No. 6 (89) pp. 17-21.

Published in issue no 6 (89) / 2011, pages 17–21.

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