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Biological and Physicochemical Study of the Implantation of a Modified Polyester Vascular Prosthesis

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Results are presented of an investigation into the susceptibility to hydrolytic and enzymatic degradation of poly(DL-lactide-co-glycolide) copolymers of varied composition. Assessment of the degradation was based on two factors: measurement of the mass loss and estimation of the molecular mass by the GPC method. The examination made it possible to select copolymers for the temporary sealing of polyester vessel prostheses. The sealed vessel prostheses manifested full biocompatibility in the range of irritating action, systemic toxicity, haemolytic action, cytotoxicity and genotoxicity. The usefulness of the polymeric material applied was also confirmed by examination of the local reaction of implants in test animals. The impact of accelerated ageing and radiation sterilisation upon the physical-mechanical properties of the vessel prostheses was also studied. The studies enabled to prepare tentative technology guidelines for the sealing of artificial blood vessels with a biocompatible and resorbable synthetic copolymer – lactide/glycolide.

Tags: vessel prosthesis, poly(DL-lactide-co-glycolide), degradtion, sealing, biocompatibility, implantation.

Citation: Niekraszewicz A., Kucharska M., Wiśniewska-Wrona M., Kardas I.; Biological and Physicochemical Study of the Implantation of a Modified Polyester Vascular Prosthesis. FIBRES & TEXTILES in Eastern Europe 2010, Vol. 18, No. 6 (83) pp. 100-105.

Published in issue no 6 (83) / 2010, pages 100–105.

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