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Activated Carbon / Dibutyrylchitin (DBC) as Fibrous Antibacterial Noncytotoxic Wound Dressing Material

Research and development

Authors:

  • Gliścińska Eulalia
    Center of Advanced Technologies of Human Friendly Textiles PRO HUMANO TEX, Department of Material and Commodity Sciencs and Textile Metrology, Technical University of Lodz, Łódź, Poland
  • Babeł Krzysztof
    Insitute of Chemical Wood Technology, Poznan University of Life Sciences, Poznań, Poland
  • Krucińska Izabella
    Center of Advanced Technologies of Human Friendly Textiles PRO HUMANO TEX, Department of Material and Commodity Sciencs and Textile Metrology, Technical University of Lodz, Łódź, Poland
  • Kowalczyk Edward
    Department of Farmacology and Toxicology, Medical University of Lodz, Łódź, Poland

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Abstract:

In this study, a noncytotoxic fibrous dressing material was developed using an activated carbon nonwoven, directly overlaid with dibutyrylchitin fibres by electrospinning. This dressing material is designed for wounds that are hard to heal. Its sorption capacity is imparted by highly adsorptive carbon fibres; when measured for distilled water, it is higher than that of commercially available silver-containing carbon dressing, and amounts to 6.63 g/g. As
shown by tests, dibutyrylchitin fibres containing a bioactive substance ensure antimicrobial action showing none of the cytotoxic effects that occur in silver-containing dressings. The tests performed for this dressing material confirm that it shows no skin and eye irritating actions, no acute intra-gastric toxicity and no effect on the values of immunoglobulin E and fibrinogen concentration, which indicates that the material produces no allergic reaction.

Tags:

wound dressing material, dibutyrylchitin, activated carbon, biocide.

Citation:

Gliścińska E, Babeł K, Krucińska I, Kowalczyk E. Activated Carbon / Dibutyrylchitin (DBC) as Fibrous Antibacterial Noncytotoxic Wound Dressing Material. FIBRES & TEXTILES in Eastern Europe 2012; 20, 2(91): 84-90.

Published in issue no 2 (91) / 2012, pages 84–90.

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