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Novel Dressing Materials Accelerating Wound Healing Made from Dibutyrylchitin

Research and development

Authors:

  • Chilarski Andrzej
    Department of Pediatric Surgery, Polish Mother\'s Memorial Hospital Research Institute, Łódź, Poland
  • Szosland Lidia
    Department of Physical Chemistry of Polymers, Technical University of Łódź, Łódź, Poland
  • Krucińska Izabella
    Department of Fibre Physics and Textile Metrology, Faculty of Textile Engineering, Technical University of Łódź, Łódź, Poland
  • Kiekens Paul
    Department of Textiles, Faculty of Engineering, Ghent University, Zwijnaarde, Belgium
  • Błasińska Anna
    Department of Fibre Physics and Textile Metrology, Faculty of Textile Engineering, Technical University of Łódź, Łódź, Poland
  • Schoukens Gustaaf
    Department of Textiles, Faculty of Engineering, Ghent University, Zwijnaarde, Belgium
  • Cisło Romualda
    Department of Fibre Physics and Textile Metrology, Faculty of Textile Engineering, Technical University of Łódź, Łódź, Poland
  • Szumilewicz Joanna
    Department of Physical Chemistry of Polymers, Technical University of Łódź, Łódź, Poland

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Abstract:

Dibutyrylchitin (DBC), a soluble chitin derivative, is a polymer with confirmed biological properties. DBC was obtained in the reaction of shrimp chitin with butyric anhydride, carried out under heterogeneous condition, in which perchloric acid was used as a catalyst of reaction. Production of DBC batches was carried out on a half - technical scale line. DBC parties were examined by infrared spectrometry, size exclusion chromatography and viscometry. DBC with molar mass of 132×103 daltons was used for the manufacturing of DBC fibres and DBC non-woven materials. DBC non-woven fabrics after γ-sterilisation were applied to a group of nine patients with different indications. DBC dressing materials were used exluding the use of other medical products. Satisfactory results of wound healing were achieved in most cases, especially in cases of burn wounds and postoperative/posttraumatic wounds and various other conditions causing skin/epidermis loss.

Tags: shrimp chitin, dibutyrylchitin, non-woven dressing, bioactivity, clinical research, wound healing

Citation: shrimp chitin, dibutyrylchitin, non-woven dressing, bioactivity, clinical research, wound healing

Published in issue no 4 (63) / 2007, pages 77–81.

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