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Investigation into Biological, Composite Surgical Meshes

Research and development

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Abstract:

A method is proposed to prepare composite surgical meshes modified by chitosan. The polypropylene mesh OPTOMESHTM Macropore is used as the half product onto which a coating of microcrystalline chitosan with a lowered pH is deposited. The thus modified surgical mesh is sterilized by means of ethylene oxide and assessed in respect to physical–mechanical and biological properties. Cytotoxicity, irritating and allergenic testing was carried out in specialized medical institutions. All examinations made of the microcrystalline chitosancoated meshes confirmed their biocompatibility as acceptable for potential uses in surgery. Hydrolytic and enzymatic degradation of the meshes was estimated, too. It was found that after 180 days the chitosan coating had lost 50% of its original weight when immersed in a bath at 37 °C containing 10 ěg/cm3 of lysozyme.

Tags: surgical mesh, chitosan, composite, biodegradation, biocompatibility.

Published in issue no 6 (71) / 2008, pages 117–121.

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