In this study two antifungal pharmaceutical agents, terbinafine and ketoconazole, were microencapsulated by solvent evaporation. Two types of ethyl cellulose with different viscosity values were used. Microcapsules were evaluated by X-ray diffractometry, DSC, FTIR and SEM analysis. Although the characteristic peaks of ketoconazole appeared in the X-ray diffractometry, those of terbinafine disappeared. The same results were observed for DSC analysis. The melting point of ketoconazole existed, while that of terbinafine was not observed. The microcapsules had a spherical shape, however the particle size varied between 5 and 120 μm. The microcapsules were applied to 100% cotton fabric. The washing of fabrics was performed in various washing cycles, and afterwards  antifungal tests were performed. The fabrics had antifungal properties against Trichophyton rubrum, which causes mycoses, up to 5 washing cycles.

" />
Where you are: Home pageYear 2015Issue (114) → Article:
AAA     ENG | POL

Antifungal Microcapsules of Ethyl Cellulose by Solvent Evaporation and Their Application to Cotton Fabric

Research and development

Authors:

Nr DOI: 10.5604/12303666.1167430

Download... PDF
Full text
Download... PDF
references

Abstract:

In this study two antifungal pharmaceutical agents, terbinafine and ketoconazole, were microencapsulated by solvent evaporation. Two types of ethyl cellulose with different viscosity values were used. Microcapsules were evaluated by X-ray diffractometry, DSC, FTIR and SEM analysis. Although the characteristic peaks of ketoconazole appeared in the X-ray diffractometry, those of terbinafine disappeared. The same results were observed for DSC analysis. The melting point of ketoconazole existed, while that of terbinafine was not observed. The microcapsules had a spherical shape, however the particle size varied between 5 and 120 μm. The microcapsules were applied to 100% cotton fabric. The washing of fabrics was performed in various washing cycles, and afterwards  antifungal tests were performed. The fabrics had antifungal properties against Trichophyton rubrum, which causes mycoses, up to 5 washing cycles.

Tags:

terbinafine, ketoconazole, cotton, ethyl cellulose, microencapsulation.

Citation:

Erkan G, Sarıışık M. Antifungal Microcapsules of Ethyl Cellulose by Solvent Evaporation and Their Application to Cotton Fabric. FIBRES & TEXTILES in Eastern Europe  2015; 23, 6(114): 125-130. DOI: 10.5604/12303666.1167430

Published in issue no 6 (114) / 2015, pages 125–130.

CONTACT:

FIBRES & TEXTILES
in Eastern Europe
ul. Skłodowskiej-Curie 19/27,
90-570 Łódź, Poland
tel. (48-42) 638-03-14
e-mail: infor@ibwch.lodz.pl
ftee@ibwch.lukasiewicz.gov.pl
Events:

EDITORIAL OFFICE
FIBRES & TEXTILES in Eastern Europe 19/27 M. Skłodowskiej-Curie Str., 90-570 Łódź, Poland e-mail: infor@lit.lukasiewicz.gov.pl; ftee@lit.lukasiewicz.gov.pl

EDITORIAL DEPARTMENT
Editor-in-Chief Dariusz Wawro, Head of Editorial Office Janusz Kazimierczak, Text Editor Geoffrey Large, Assistant Editor Anna WahlProduction Łukasiewicz-ŁIT

facebook