Abstract:

In this study two antifungal pharmaceutical agents, terbinafine and ketoconazole, were microencapsulated by solvent evaporation. Two types of ethyl cellulose with different viscosity values were used. Microcapsules were evaluated by X-ray diffractometry, DSC, FTIR and SEM analysis. Although the characteristic peaks of ketoconazole appeared in the X-ray diffractometry, those of terbinafine disappeared. The same results were observed for DSC analysis. The melting point of ketoconazole existed, while that of terbinafine was not observed. The microcapsules had a spherical shape, however the particle size varied between 5 and 120 μm. The microcapsules were applied to 100% cotton fabric. The washing of fabrics was performed in various washing cycles, and afterwards  antifungal tests were performed. The fabrics had antifungal properties against Trichophyton rubrum, which causes mycoses, up to 5 washing cycles.